NEW Drugs for COVID Treatment and Prevention

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NEW Drugs for COVID Treatment and Prevention

Could an antiviral medication called Molnupiravir eliminate SARS-CoV2 from an infected person’s nose and throat?

This oral medication, taken twice a day for five days, was initially developed to treat influenza. However, Molnupiravir seems to also be effective against SARS-CoV-2.

A phase 2a study has recently been completed. It enrolled 202 non-hospitalized adults with signs and symptoms of COVID and confirmed infection. At baseline, 42% of participants had detectable levels of SARS-CoV-2 virus when cultured.

The study had three treatment groups, arms, taking 200 mg, 400 mg, and 800 mg of Molnupiravir, respectively, and a control group. Participants’ noses were swabbed on days 3,5,7,14, and 28.

A reduction in SARS-CoV-2 was noted in all treatment groups but was only significant in the 800 mg group. Therefore, a much larger phase 3 trial is underway with 1300 participants.

Molnupiravir works by introducing copying errors when viral RNA replicates. Like DNA, RNA comprises four different nucleotides: adenine, cytosine, guanine, and uracil.

Molnupirivir exists in two forms. In one form, it mimics cytosine, and in the other form, it mimics uracil. When SARS-CoV2 grows in this drug’s presence, its RNA-dependent RNA polymerase (the enzyme that reads RNA) reads cytosine as uracil and puts the wrong nucleoside in the RNA sequence.

This misreading creates a massive number of mutations in the viral genome, rendering the new RNA useless.
Molnupiravir was originally developed at Emory University and was later acquired by Miami-based Ridgeback biotherapeutics, who later partnered with Merck & Co to develop it further. In April 2020, a whistleblower complaint by a former head of BARDA, Rick Bright, expressed concerns that similar drugs could damage DNA.

Bright notes in his complaint that “similar experimental drugs in this class had been shown to cause reproductive toxicity in animals, and offspring from treated animals had been born without teeth and without parts of their skulls.”

George Painter, CEO of Drug Innovation Ventures at Emory (DRIVE), replied, “We haven’t seen robust evidence for any sort of mutagenicity as had been seen in the past [by Schinazi and others].”

In the phase 2A clinical trial, seven participants discontinued treatment though only four experienced adverse events, none of which were considered related to Molnupiravir. However, the trial is still blinded, so what the exact adverse events were is not known.

Several other antiviral drugs for COVID are developing, like Upamostat (RHB-107), AT-527, and favipiravir.

And what about COVID Prophylactic drugs?
Let’s say you are exposed to someone with COVID. Is there a post-exposure prophylactic drug you can take?
In December 2020, researchers at Georgia State University published a study in Nature Microbiology that showed that giving Molnupiravir to ferrets infected with SARS-CoV-2 prevented transmission to uninfected ferrets housed in the same cage. So this is great news for ferrets. Human trials should be coming soon.

What about another treatment option for COVID that must also be given early in the illness, monoclonal antibodies?
SARS-CoV-2 uses a spike protein to attach to the ACE-2 receptor and then enter human cells. Monoclonal antibodies bind to a specific protein surface, meaning antigens. These monoclonal antibodies bind to the spike protein of the virus, preventing it from invading human cells, and at the same time, it tags it to let the immune cells know that it can destroy it.

Monoclonal antibodies can be produced by exposing a mouse or a hamster to an antigen, and the antibodies made are collected.
Today antibodies can be made in the lab and treat nearly 100 conditions, including cancer and autoimmune disorders.
The monoclonal antibodies used to treat COVID include Regeneron’s clone of an antibody harvested from a person who recovered from COVID and an antibody harvested from a genetically modified mouse engineered to have a human immune system.

Eli Lilly’s monoclonal antibody Bamlanivamab was identified in a blood sample from a patient who recovered from COVID.
Clinical trials show that monoclonal antibodies can prevent deaths and hospitalizations in people with mild to moderate COVID who are at risk of severe disease.
A study of VIR-7831, a product made by VIR and GSK, reduced the chances of hospitalization or death by 85%. In addition, a randomized, double-blind, placebo-controlled phase 3 study showed a cocktail of two antibodies- Bamlanivimab and Etesevimab, both made by Eli Lilly, cut the risk of hospitalization death by 87%.

Doctor Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
Website: https://doctormikehansen.com/
Doctor Hansen’s Courses: https://doctormikehansen.com/courses/
Contact and Social Media Links: https://doctormikehansen.com/contact/

#covid #coviddrugs
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20 Comments

  1. Courage Ese

    My herpes virus was eliminated with the help of DR AJAKAJA powerful natural herbal remedies nothing like natural. you can get in touch with him on his YouTube channel..

  2. Todd Martin Tschanz Schaefer

    Thank you so much for your videos. I really appreciate your information and updates and rely on your honest reporting! Be well! Many things make sense and are understandable to people outside the medical profession.

  3. Sophia Mia

    In discussion with my friend she said that she will never make payment to any medication when I ask why? She said four consecutive times she ordered and she didn't see any, I feel for her anyway because is not easy to be disappointed but, I told her my product is arriving US tomorrow according to DR RORPOPOR HERBAL on YouTube and it was so, not only that I got healed just within 17days of usage. And my friend who said over her dead body will she order for any medication is now asking me to give her the doctor number. May you live long to heal more souls👯👯

  4. Eileen Lord

    Should be Treating this virus by now…#1 Treatment

  5. Fffd Raymond

    With gratitude in my heart I wanna say a very big thank you to dr udoka on YouTube for helping me eradicate Genital herpes permanently

  6. Lane Newton

    What an actual medical treatment that can be prescribed for those with Covid…weird the government wants you to believe that vaccine is a medical treatment…its not its preventive!!

  7. Vatomatic31

    I got the virus in December 2020 and in Cincinnati my experience was that doctors aren’t doing anything to treat it. They literally tell you to go home, rest, and take Tylenol, no other treatment was mentioned or offered. I did eventually get better. But in my opinion a lot of doctors don’t deserve a pat on the back because they aren’t doing anything. The patient is the one getting themselves better. 6 people in my family got it and no one was offered any of these treatments.

  8. Victor Barry

    It was a great breakthrough for me to be cured of herpes virus with Dr Madida herbal cure I found out about on YouTube by searching for Doctor youtube channel with Dr Madida.

  9. Aifa Austero

    How about HIV positive people ?are we have done studying a medicine for the people got affected ? Thank you ❤️❤️😊

  10. yz

    iver mectin in a new wrapper, the wait has caused thousands of DEATHS.

  11. Eve Price

    There are several medicines, herbal & non-herbal, to remarkably treat people with covid, but the Governments keep banning them because they are cheap, and not profitable and they make far more money on sick people. They say, "It cant be trusted because there has not been sufficient studies to prove they work….but their vaccines are also experimental & adverse affects are VERY well known, but they have no problem pushing that on people. Excuses. The truth is…these treatments do not line up with their agendas. Just like there has been cure for cancer for long time but is still denied for same reasons. Also, if you google the "world economic forum"…. or "the great reset"….or "the Georgia guide stones"….you all will see that it is about more than money. Our governments are using the pandemic to initiate the great reset. They openly admit to this… And it is all public information. Just look it up.

  12. Badr ismail

    how long this dr been in game to know … i seen his videos nothing to know

  13. Yoshifer

    Even if you are vaccinated, still wear a mask at all times. Maintain social distancing and be vigilant. Keep away or don’t talk to someone that has not wearing a mask.

  14. brainretardant

    Colonial silver is effective against filoviruses, I'm fairly certain it is also effective against sers corona event 201 psyop kuhl virus

  15. brainretardant

    Deepstate wouldn't have released this on us unless they had a pharmaceutical cure. Everyone knows there has never been a successful RNA virus vaccine. Once u accept the sers was modified and released to necessitate the vhax everything makes sense. The kull is on, that's why the huge push to force vhax everyone.

  16. sorryliars

    If everyone gets vaccinated how would we know these work or need these lol hmmm

  17. Mona Singh

    If yr mask washable…please was before using…even packaged need this…

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