Irritable Bowel Syndrome: Pathophysiology, Symptoms, Causes, Diagnosis and Treatment, Animation

Irritable Bowel Syndrome: Pathophysiology, Symptoms, Causes, Diagnosis and Treatment, Animation
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Irritable Bowel Syndrome: Pathophysiology, Symptoms, Causes, Diagnosis and Treatment, Animation

(USMLE topics) IBS: Prevalence, signs and symptoms, types of IBS, pathophysiology, different possible causes and mechanisms, diagnosis and treatments. This video is available for instant download licensing here:
Voice by: Marty Henne
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All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Irritable bowel syndrome, or IBS, is the most commonly diagnosed gastrointestinal disorder, affecting at least 10% of the global population. IBS is characterized by chronic or recurrent abdominal pain, associated with a change in bowel habits. Most patients can be classified, according to their predominant stool pattern, into IBS with diarrhea, IBS with constipation, or mixed-stool IBS, in which diarrhea alternates with constipation. Other symptoms may include mucus in stools, bloating, gassiness, and feelings of severe illness. IBS symptoms can be triggered by certain foods, stress, and often get worse around menstrual periods in women. People with IBS are also likely to have other disorders such as fibromyalgia, major depression, or chronic fatigue syndrome.
IBS occurs more frequently in young adults, and affects more women than men.
IBS is a functional disorder, meaning the bowel does not function properly, but there is no observable structural damage. It is thought to associate with problems in the communication system between the gut and the central nervous system, known as the gut-brain axis. This system not only ensures proper functions of the digestive system, but also adapts digestive activities to the body’s different physiological states. Basically, sensory nerve endings in the gut transmit information about the intestinal environment to the brain. The brain integrates this information with inputs from the rest of the body, and sends back neural and hormonal signals to control various gut activities. For example, intestinal muscle contraction is regulated so that the bowel moves food at an optimal pace, allowing the body to reabsorb the right amount of water and nutrients before stools can form.
IBS patients often have irregular intestinal motility patterns. When food moves too fast through the intestine, less water is reabsorbed and stools become more watery. When food moves too slowly, more water is reabsorbed and constipation results. Sensory nerve endings in the bowel of IBS patients are also more sensitive, or “irritated”, producing the sensation of pain. This is known as visceral hypersensitivity.
IBS is classified as a syndrome, meaning a group of symptoms, rather than a single disease. This is because distinct underlying mechanisms may drive disease progression in different groups of patients. Several possible mechanisms have been identified. These include:
– alterations in brain function caused by psychological trauma, anxiety, or stress;
– intolerance to certain foods, such as short chain carbohydrates, gluten, dairy products;
– post-infectious changes, such as low-grade inflammation or altered intestinal permeability;
– disturbances in the gut microbiota;
– abnormalities in serotonin metabolism;
– and genetics.
It is common for IBS to result from a combination of several of these factors.
Diagnosis is based on symptoms, but tests are done to exclude other more serious conditions such as inflammatory bowel disease and cancers. The latest diagnostic criteria (Rome III criteria) include: abdominal pain or discomfort lasting at least 3 days a month in the last three months, associated with at least two of three factors: relief upon defecation, pain onset associated with a change in stool frequency, or pain onset associated with a change in the form of stool.
IBS rarely requires hospitalization and does not increase risks for colon cancers. Current treatments aim to relieve symptoms, which, in most people, can be managed with diet, and stress reduction. Severe cases may be treated with medications.

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  1. Alila Medical Media

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  2. Sam Taylor

    I lost my mom then my baby 1 month apart. Then our house flooded, moved into a new condo where the landlord keep trying to "get" with my husband.. moved out. Kept getting one abusive job after the other, literally quit a job every 6 weeks. Once life settled down a bit I got addicted to eating sugar. Booooooooom then and now I have DEBILITATING constipation. Hospitalized type constipation. I know can only eat 5 things and I'm in pain ALL OF THE TIME. I am on a high dose of magnesium so that's at least helping with going to the bathroom. But I do think my past, all the stress caused this. And now I have severe anxiety over this and the pain. Lol Im desperately trying to meditate and stop being so angry and stressed out. Bless anyone who has this awful issue xo

  3. Brainstorming & sharing


  4. ankur tripathi

    take phsylium husk on regular bases half teaspoon twice a day with 1 glass of water one after breakfast and second 1 hour before bedtime then see the magic i had ibs for very long last year i find this cure trust me bro its a life changer and its 100% natural so you can take this for long term no side effects at all reply me after try i hope this help someone

  5. Mo

    My whole life i had constipation same with all my family members, they can't go a day without taking senna powder to help with bowl movement, me on the other hand i started taking anti diarrhea medication so i don't have to go to the bathroom 6 times a day


    I was suffering from IBS from 4 months. I was very confused for 4 months. Now i cured it fully in 10 days. I started drinking rice water half hour before and after every meal. I did kapalbhati 20 min, anulom vilom 10 min, soham for 10 min twice a day. And most effective exercise is plank exercise. It will develop self strength and self energy in cells of intestine. I eat rice initially for 5 days then start chapati. I eat 1/4th less food then my hunger because it will give load on intestine. I don't eat any milk product except paneer and butter milk. Less spicy food. And drink 5 litres of water daily. And most important is stress. For that i did meditation regularly. Consistency and dedication is most important if you want to become healthy in all manners.

  7. mustafa Ibrahim

    Ibs is a nightmare just thinking about it.
    I stay away from all the foods that they say cause it but it’s crazy how I eat normal things sometimes in very small portions and get the most unbearable abdominal pain. And I also eat things that should trigger IBS but nothing happens!! So it’s very unpredictable really !!

    The pain is usually on my middle upper abdominal area but can also shit to the sides.

    It sometimes starts with heartburn and slowly develops into bloating and the worst painful cramps. I feel like I’m too full and gassy and I can’t release any gas. No amount of water can solve the issue. It also sometimes feel like drinking water can make the situation feel worse. And then comes Constipation.

    The worst pain is when I wan to sleep or during sleep. I sometimes wake up from the pain and find myself in face down ass up position.

    I also sometimes make my self throw up to ease up the discomfort.

    It sometimes last a day or 3 days sometimes 4.

    Nothing I tried worked. The worst for me is the pain. Unfortunately it’s not like a headache, you can’t just take pain killer for it. All anti spasms medications didn’t manage the pain much for me.

    My problem with all the advices I got from doctors or saw online they don’t touch much on pain management.

    Peace and love ☮️ ❤️
    Please share your experience with me and if you relate I would appreciate some advice on pain management

  8. Ziggystardust_0108

    I been dealing with ibs symptoms since I was 14 and I'm now 23😓

  9. Daniel Warrior

    I developed IBS last year and stress makes it hurt so much and I dont know why but the pain hasnt stopped for over a week now and I cant take this much more, its so painful that Im going crazy

  10. Jerome Harris

    All you need to do is eat a lot of cut up raw foods then drink some beer fast so you can burp them run on the trail med to your stomach lock up thank me later

  11. Joes Ra

    I've always been a stressful student and my grades meant so much to me. Before every exam my anxiety causes diarrhea but it's a vicious loop cause then my diarrhea causes more anxiety because I'm afraid to be late for the exam. Years later I'm a med student. Nothing changed, I get diarrhea before every exam it's a nightmare. Now that I started doing shifts in the ER it's so intense and stressful. I couldn't take it anymore. I'm finally going to see a therapist next week.
    Please seek help, anxiety never really leaves you, it'll always resurface, don't let it control your life like I did.
    Straight A students, I'm talking to you especially.

  12. All the Things with Juliet

    Depression and PTSD totally could have done it to me bc I never had IBS and after my first ever panic attack this happened and got worse !

  13. waqar jamil

    I am a men who has this I feel like a female after watching this 😭😭😭

  14. Devendra Bhalekar

    Sir mera sath 1 month pahale incident kai 1 din pahale stomach mei gole jaisi feeling ari thi…..or dusra din office mei kaam karte karte achanak sei large intestine upper ki taraf movement jaise feel aya jorse …fir sweating, dizziness.heartbeat baad gai kuch sec kai liya ……then kuch dinobad gerd kai symptom show hone lage …..thodisi swelling hai upper left abdomen mei rib kai niche. But no pain at all since day 1 …..stool green hora hai …..kai yha IBS ha yha IBD plz help any one

    Reply help

  15. YOUmommaHAX

    I been diagnosed with this as I been having diarrhea for about 3 years now. Along with diarrhea I also have an unbearable pain in my stomach, it's so bad and my stomach always hurts is that a normal part of IBS? I'm starting to think the pain and discomfort in my stomach is a separate issue from the ibs

  16. Tyree Wadsworth

    Ok I feel better knowing this I definitely have IBS so I know why I feel this way

  17. abhishek verma

    I think stress exam trigger ins in my body I fell little little pain and uncomfort in right side of abdomen clinical test are fine

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